I hang out mostly with non-furries actually. I find it a better use of my time to associate with all types of people 
I am in the same scenario as Drake. In fact, I even have friends who make quips like "it's all the furry's fault." Do I care? God no I don't. I understand the negative sentiment against the fandom may cause others to socially and physically withdraw from all other contact, but generally why that happens is because some people just don't have enough pride or self-esteem to do anything - their lack of self-esteem keeps them from thinking they can acquire self-esteem. Honestly, that is a rant on its own for me.
To note those who fear the comments of non-furs, get used to it. Even furries discriminate among one another. In the words of 2, the Ranting Gryphon: "So, what, do all the mythical creatures take a back seat on the bus because we're not realistic enough?" So even while a lot of the fandom can be accepting, yet more are not. The same can be said for religion (and atheism), politics, and so forth. No place is safe, so restricting oneself to one demographic still makes you no better off, if it doesn't make things worse.
And just to say, if you commune over the internet, you're not necessarily isolated. You're expressing that part of you that would show when you would get with people in real life; even the meme references and such. Sure, you're isolated from physical presence, but you're still talking with people, aren't you? Well, I hope you are. Clever Bot isn't exactly brilliant company.

I understand where you come from, Ottersmash. I see it too, with so many. But it's that desire to be with people who agree, not disagree; how many people
want disagreement, or
like disagreement? I doubt there are that many. That's what a friend is, to some extent, right? A person you agree with, trust and who respects your differences? We already restrict ourselves. We don't hang out with people we always disagree with. So why limit yourself so narrowly? It's to eliminate that chance of disagreement as much as possible. Honestly, what will one do when one
HAS to go out? Just sit in a corner and hide? That is what gets people mocked, being afraid of associating even the most kind and gentle people. Come on, a lot of people want to give you a chance, don't turn them away.
I don't try to date solely furries, either, like Valdyr brought up. But the strange incident is that I often end up dating a furry/scaly; out of a chance of I don't know what, I have dated two female furries now, the first I didn't even know about her fandom inclusion. But it happens to me with online friends, too. I always make friends with furries, it seems; not many of my watchers are non-furs. I am friends with all the furries at my school, as well; hell, even a brony or two. But no matter, my non-fur friends outnumber my furry friends. Probably sixty-plus percent are non furs irl? I'm even friends with a fur hater, two in fact.
Humans will naturally seek out those who share ideals and ideas with them, so I can't blame the isolation seekers, but I sure would never be happy as one.
*insert Sne's utter brilliance here*
Agreed, with all of it. You know, to be honest, some of that could cheer up them emo kids, too.

But to be serious, I've never had the crutch to hold me up, even when my legs were broken, I had to stand up myself; with minimal intervention. To be blunt, I should be the one isolating myself for all time, based on my life. Even if yours is worse than mine, it doesn't do to run away, because then you never find an answer. Don't you that isolate yourselves
want the feeling of people caring? Only way to get that, if it truly is your desire, is to do as Sne said and stand up; if you never stand up, you won't be moving anywhere. Only the good things in life are worth fighting for, so expect adversity when striving for the best. Holing up only makes you weaker to it.
For those who have played Pokemon, think about this matchup: Water/Ground Versus Grass. Who wins? You'd think grass, right? Not if you prepare properly. Give that water/ground type the right items, and the right moveset, and it will decimate the grass type. The same goes for preparing to fight adversity on your attempt to get moving. And if you fail, giving up will only leave you worse off. Once you start, you should never stop. To reiterate Sne, be brave. Advocate yourself; because in reality, you're the one who decides if you get to be happy, sad or mad. And the last time I checked, nobody wants misery or frustration.
I've seen the greatest things in people, and I have seen the worst. And like within the fandom, the negative stands out more than the positive. But you have to perceive the positive for it to be tangible. If you don't, of course you'll think your life is awful.
Your life is your choice, not anyone else's. Even if you're dying, you have a choice. So be alone, or find more of those people who agree and accept you?