F-Zero.
We had it on the SNES, the N64 (F-Zero X still feels fast 10+ years later), GX on the GameCube (way too hard >.<), a few on the GBA...so it's not exactly a "dead" series, but why haven't we seen a F-Zero game on Wii, DS or even DSi?
I can imagine it working execellently on the wii and it'd be nice to have a true-3d F-Zero game you can carry around with you, experiencing those intense speeds whilst the bus is held up in traffic
I have played F-Zero Climax for the GBA. One word describes that game. Frustrating!!! With a capital F! It's almost impossible to get first place on most races, and some races have these impossible jumps that are only possible with a booster, which you can't get on the first lap. If they toned down the difficulty a little in a new game, I would buy it. But if they make it super frustrating like Climax, then there are going to be alot of broken game systems.
Edit: Okay, the reason it's been so hard is because I wasn't using the Elegance Liberty. That ride is cheap, cheap, CHEAP!!! Not only is it fast, but it has excelent turning abilities. Common sense would say slower vehicles would have better turning than faster vehicles, but in this game, the slower vehicles have pathetic turning and the fast vehicles are the ones with good turning. Earlier, I almost snapped trying to defeat those two really ugly guys at a breaking contest, but it's pretty much impossible without a break button. This might actually be the chalange for slow vehicles.