Well, there are many things that they've completely rebuggered for this film, other than Piccolo looking like an albino vampire:
-Goku is no longer a young mountain child, but instead an unpopular high school student
-Bulma's hair is not blue, or even purple as in the manga. I've seen a photo where she has a couple of blue strands, but the rest of her hair looks normal.
-Chi-Chi is an accomplished martial artist who a shy Goku has a crush on. Chi-Chi has a boyfriend already.
-Mai is not Pilaf's subordinate - in fact, Shu and Pilaf are nowhere to be seen. Instead, she's Piccolo's shapeshifting lackey.
-Grandpa Gohan is still alive as of the beginning of the film.
-Kamesennin (Master Roshi), played by Chow Yun Fat, looks just like Chow Yun Fat in a Hawaiian shirt and with a mustache. As someone elsewhere pointed out, he looks just like someone kidnapped Fat on vacation and forced him into the role. He honestly looked more like Roshi in Pirates of the Caribbean: At World's End - sure, Sao Feng may not have had a full-on white beard and sunglasses, but at least he was bald and had more facial hair than Fat's Roshi!
-Instead of Kurilin, Goku's best friend is some random kid named "Weaver".
