How about rather than a whole galaxy, if it's the year 3000, the setting being the Solar System.
The energy crisis of the mid 21st century could've come to an end with the production of the worlds' first viable fusion reactor in the late 2060's. This resulted in a race of space exploration as greater resources of Helium-3 were required to sustain fusion reactions.
As space was increasingly explored, humanity developed genetically engineered 'assistant' workers to assist with space exploration and working in hostile environments. Alongside this the development of exoskeletons for use in space and heavy environments was undertaken, with breakthroughs in materials science allowing for high strength, light-weight materials, such as carbon-carbon steel, and nanotube materials.
This golden age lasted for a while as exploration flourished, with many new settlements being established on moons, asteroids, in orbit of planets and even on the surface of worlds under pressure domes. Terraforming efforts are being started on Mars, and some of the lowest-lying canyons have persistent atmosphere which can be inhabited only with thick clothing and respirator masks, rather than full pressure suits.
In orbit of other planets, numerous space installations and colonies exist.
Things are growing strained, however, as numerous activist groups have formed for the rights of the 'servant' races, who have become recognized and free citizens in the worlds around Jupiter, otherwise known as the Jovian Confederation.
They have proved their own sentience and sapience on numerous occasions have demanded that their people be freed and the outlying worlds and settlements. This has lead to an undercurrent of dissatisfaction and aggression among the population of genetically engineered persons (GE's, or 'Gennies') throughout the solar system.
The colonies, forming their own way of doing things and working to their own schedules and independent routines to suit their populations, are looking to become self-governing and independent from an increasingly over-populated and militaristic Earth, which seeks to influence and control policies and the way of life on its' outer settlements.
With Mars reaching a level of habitable and self-sustaining life, it is the focus of eyes all across the system, as both the Earth Government and the Jovian Confederation build up their forces around the area, including the newly built and designed combat frames, due to see their first true mass deployment on and around the surface of Mars, and potentially further.
All it will take is one incident to light the powder keg, and topple a tense situation of minor quiet sirmishes into full-blown war...